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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for 프라그마틱 정품확인방법 무료스핀 (http://Antiaginglabo.shop) pragmatic trials to be valid and to reduce bias in the results is also essential. However too much heterogeneity could result in issues with the design of the trial.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers to help inform their decisions. They can also be a great method of determining the causal relationship between an intervention and its results. They should, however, not, be used to replace explanation studies.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study that includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary-care settings.